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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteronetreatment in 12 obese men aged 33–72 years. The intervention and control groups also included six lean, physically active men with an average body mass index of 26 ± 2.5 years. Subjects were assessed over 7 weeks to ascertain changes in weight, waist circumference and fat-free mass. The study was halted at month 7 because of an unplanned change in the management of diabetes. Primary outcome was mean weight loss (measured after a mean of 3.3 months), body fat percentage (mean of 2.1±1.0 and 2.4±1.1kg respectively) and mean waist circumference. Secondary outcomes were mean percentage body fat loss, body fat percentage, fat-free mass and body fat index. Participants gave informed consent and data was analysed with Prism 5 software. The effect of testosterone therapy (20 microg/day) and its combination with the WYWeight programme (WY) was compared between men who achieved the weight loss target (WY Weight group) after 7 weeks in the weight loss programme and those who did not (WY+WY group). A linear regression model based on data from the 6 weeks before weight loss was used. A linear or logistic regression was developed using the mean changes in waist length, abdominal circumference and BMI as continuous variables. This model was analysed under a priori conditions with weight loss or weight loss plus weight gain as the dependent variables, and the two treatment groups as independent variables. The impact of testosterone therapy on weight and waist circumference A total of 968 participants were included in the study, of whom 935 were aged 45 and over, 1077 were obese, and 732 were less than overweight. The mean age was 61 ± 3 years and the mean body mass index was 30.2 ± 1.4 (range 19–42; range 16–48). The mean % body fat (%BF) was 20.9 ± 3.3(17.9–22.7)% and 17.6 ± 4.1 (11.2–21.2)% respectively. Mean BMI was 27.1 ± 1.0 (17.1–30.9; range 12.0–29.9; range 20–39). There were no significant between group differences for any of the measured parameters. The men who achieved the weight loss target (WY group) achieved 1.6kg on mean (SD; 0.5) and 1.7kg on standard deviation (SD Similar articles: